Ethical Selling Essay Example for Free

Ethical Selling Essay In this contemporary period, most consumers base their confidence concerning products and services on their popularity. Famous brands which are used by known and prominent celebrities and personalities are often patronized and trusted by the majority of the consumers (Bannister Bonnice, 1986). Yet the quality of these brands is not really known to the consumers unless they start using the product or once they avail the service. Nevertheless, known and widely-used brands of products or services, being patronized and recognized by most consumers, do not only go with the idea that they have to gain much profit. In deed, they have to ensure their customers and clients that their products or services are of high quality in order to ensure also that there would be a good profit that would come to them as exchange for maintaining superior and trusted quality of their products or services. Yet, not all consumers base their purchasing attitude solely on the quality of the product or service. They also consider the price. The cheaper the price of the product or service, the more the consumers are attracted to buy them. But this does not suggest that all consumers are after cheap prices. However, there are some consumers who neglect the quality of the product or service just to have them at cheaper and more affordable prices (Bannister Bonnice, 1986). For these reasons, the highlight of advertisement is not on the quality of the product or service but more on its price. And the quality that is supposed to be the thing that the manufacturer and the consumer should uphold is being neglected in a way that some manufacturers make fake demonstrations in advertisements just to market their products or service. Many of these products are often found in T. V Shopping advertisements in which the consumers cannot really test the durability, the quality, or the serviceability of the product. But because the advertisers are so good in making fake demonstrations, they easily deceive and attract consumers to buy their products (Cook, 2001). An example product that is being advertized at televisions as well as internets is a carpet cleaner named Bosun 12v Cordless Wet and Dry Vacuum. It is a handheld vacuum cleaner that can be used to clean wet and dry spills on carpets. A particular television station airs numerous advertisements of products and services. And one of the products that is being advertized in that television station is Bosun. Yet, the product is questioned for its quality when one of the costumers complained that Bosun has a low quality and that it only works for three to five weeks. Also, the costumer said that the product is defective in a sense that it does not really clean wet spills on carpet which is included in its advertisement as one of its unique function. However, the manufacturer of the product claimed that their product is not defective. Truly, deception in marketing is being employed by some manufacturers to gain much profit for their own sake. They do not realize that their function is to provide good and efficient products to the consumers and not to harm or deceive them just for their own interest (Cook, 2001). As claimed by the Utilitarian Principle, producing the greatest good or greatest happiness for the greatest number is the standard of what is right or wrong. If this principle would be used to evaluate the above scenario, the manufacturer of Bosun failed to act morally. Also, if the Kantian Ethics would be used to evaluate the given case, the manufacturers of Bosun would still be labeled as immoral for they failed to do their duty –that is providing good and efficient products for the consumers (Beauchamp Bowie, 2003). There are many reports about fraud advertisements, in televisions, radios, print materials, and internet (Cook, 2001). And truly, there are laws that condemn the act of it. Yet, many are still practicing fraud advertising for the sake of obtaining more money. They failed to follow the Categorical Imperative suggested by Kant that is to always treat human beings as ends and not merely means to an end. This entails that manufacturers and advertisers must respect the consumers’ rights and not use them for their own advantage (Beauchamp Bowie, 2003).

Cellular Metabolism and the Immune Response Control

Cellular Metabolism and the Immune Response Control PRESTES, A. F. R. O.1; KONDO, F. V.2; HUETE, G. C.3; MURILLO, O.4 Keywords: mTOR, metabolism, Akt, immune system, regulation, mitochondria, inflammatory and anti-inflammatory I. Introduction Metabolism and immune system: The metabolic system was seen only as a system of power generation and metabolites for the functioning of cells. Today we know that changes in metabolic regulation may interfere directly in diseases that involve inflammatory processes. Thus, knowledge of the relationship between metabolism and cell signaling helps in understanding metabolic disorders, cancer, and also in the study of immune response (1,2). The relationship between metabolic and regulatory aspects of the immune system is not yet fully known. Even with major discoveries on the subject, the metabolism of many cells of the immune system is unknown (1,2). The metabolic changes during phagocytosis of three types of immune cells from pigs, leukocytes and peritoneal exudate monocytes and alveolar macrophages. In this study it was observed that macrophages depend on oxidative phosphorylation to produce energy during phagocytosis, whereas the other two cells only use glycolysis to produce energy (3). Another study confirms the close relationship between immune system and metabolism, which showed that incubation of dendritic cells (differentiated in vitro) with LPS provides an increase in glucose consumption, increased formation of lactate and reduction in oxygen consumption. Furthermore, these changes also reflected in increased CD86 co-stimulatory molecule indicating a functional modulation of these cells (4). The need for meta bolic resources to build active components of the immune system, the messenger function of certain classes of metabolites and metabolites, and the intimate relationship between parasite and mammalian defense mechanism, which is probably immune regulatory events are reflected in the metabolism (5). The metabolic profile of the cells of the immune system is also important to provide a tool that generates a systemic metabolic description induced by the parasite in the host, promoting a new direction of the immune response during infection by the parasite (5). In most biological systems, there is a stimulus that triggers an effector response, which usually makes the system back to the starting point. Although having different primary functions, the immune system and metabolic pathways are arranged in the same manner as in serum glucose levels in thermogenesis or bacterial infection, where the lipopolysaccharide stimulates TLR-4 receptor, which promotes the release of TNF-ÃŽ ±, improving bactericidal activity and vascular permeability reducing infection (2). Metabolism and associated pathways Akt/PI3K/mTOR: As well as the metabolic pathways generate energy, the means of regulation of protein synthesis involves several intracellular signaling pathways such as Akt as Akt (serine/threonine kinase), expressed in heart, lung, brain and skeletal muscle. Various stimuli, such as cytokines, growth factors and hormones, are responsible for the phosphorylation and activation of Akt, which is composed of three members, Akt1, Akt2 and Akt3 (6). The Akts proteins are recruited to the plasma membrane by PI3K, which acts as a lipid kinase. The Akt/PI3K pathway operates in promoting cell survival through evasion of apoptosis and cell proliferation through activation of mTOR in response to nutrient availability and to stimulation by growth factors. The mTOR protein stimulates translation that is required for cell cycle progression (7). mTORC1 activation is indirectly given when Akt phosphorylates TSC-2 one of the molecules of heterodimer TSC1 and TSC2, this activates the GTPase function of this heterodimer which reverses the inhibition of mTORC1, inhibiting RHEB to pass the ADP to ATP linked to this protein, by activation of cyclase function of the TSC heterodimer (8). Akt phosphorylation is important for neutralization and PRAS40, important for the activation and interactions mTOR1 and mTOR2 with their substrates (9). Thus, the mTOR pathway is also known as PI3K/Akt/mTOR. Despite the multiple substrates involved in this pathway. Additionally, Akt is not limited to this path and fulfills other functions at the cellular level. Metabolism and mTOR: Mammalian Target of Rapamycin is a serine/threonine protein kinase involved in regulation of many cellular events, such growth, survival, function, metabolism, and differentiation. It is constitutively expressed, and its regulation occurs predominantly post-translationally (7). This protein was discovery from searches about target of Rapamycin, that was originally found as a growth inhibitor which have immunosuppressive and anticancer properties (10). Additionally, due to the ability of mTOR activation to regulate metabolism, it promotes a crucial link connecting metabolic demands and cellular function (7). This link is mediated through the control of key transcriptional regulators. (11). mTOR fathers two functionally distinct signaling multi-protein complexes: mTORC1, which is composed of the scaffolding regulatory-associated protein of mTOR (RAPTOR), DEP domain containing mTOR-interacting protein (DEPTOR), Proline-Rich Akt Substrate 40 kDa (PRAS40), and mammalian Lethal with Sec13 protein 8 (mLST8); and mTORC2, which is composed of RAPTOR-independent companion of TOR (RICTOR), protein observed with RICTOR (PROTOR), mSIN1 proteins, mLST8 and DEPTOR. The connection of mTOR with these adapter proteins has functional distinct consequences (3,4). II. Metabolism and T cells differentiation Such described previously, the mTOR ability to play a role in cellular differentiation occurs through the regulation of transcription regulators. Follow, some these regulators and its role in metabolic programs regulation. HIF-1: The Hipoxia-inducible Factor is a hetrodimeric protein which regulates the expression of various genes crucial for cellular adaptation to a low-oxygen environment. This protein supports the differentiation of naà ¯ve CD4+ T cell to Th17 cell through the stabilization of the RORÃŽ ³t expression, as well as inhibits Treg differentiation through the inhibition of Foxp3, mediating its proteosomal degradation (3,5). Myc: The oncogenic transcription factor Myc regulates various metabolic pathways essentials for cellular growth and proliferation, such glycolysis, glutaminolysis, and fatty acid oxidation (14). PPARÃŽ ±: The peroxisome proliferator-activated receptor ÃŽ ± (PPARÃŽ ±) is a nuclear hormone receptor that regulates fatty acid metabolism and glucose homeostasis, playing a role as a intracellular sensor of endogenous fatty acids. This receptor induces Treg differentiation and inhibits effector differentiation (11). PPARÃŽ ³: Like its homolog PPARÃŽ ±, PPARÃŽ ³ is a nuclear hormone receptor that regulates adipogenesis, lipid metabolism and glucose homeostasis in cells. This receptor plays the same role in T cell differentiation (11). SREBP: The sterol regulatory element binding proteins (SREBP) plays a critical role in regulating cellular lipogenesis, facilitating the anabolic enzymes transcription, which is involved in cholesterol and fatty acid synthesis (11). This protein was found to associate with the IL17 promoter, where it interacts with and inhibits the activity of the aryl hydrocarbon receptor. This transcription factor is known to be important for expression of Th17-associated genes (5,7). Once the antigen is recognized, the integration of many factors from the microenvironment gives the effector fate of the naive CD4+ T cell. Until now, the T-cell subsets have been characterized only by their transcription factor expression and cytokine secretion profile. Nevertheless, it has currently proposed that each T-cell subset also hold a single metabolic profile and a corresponding set of signal requirements of mTOR complexes (11). According this metabolic classification, the T-cell would present these features: Th1 T cells phenotype exhibit a strong glycolytic phenotype and express high levels in surface of the Glut1 glucose transporter. Its development is dependent on the mTORC1 signaling complex (3,8). Th2 T cells phenotype also express high levels in surface of the Glut1 glucose transporter and exhibits a high rate of lactate production and glucose uptake following stimulation. These cells can develop in absence of mTORC1 but are dependent on the mTORC2 signaling complex (3,8). Th17 cells phenotype is the higher glycolytic T-cell subset. The IL-17-secreting CD4+ T cells development drastically decreases in T cells lacking mTOR, mTORC1 and treated with Rapamycin. Nevertheless, T cells lacking mTORC2 does not appear to have its development inhibited (3,8). Treg cells phenotype exhibits an oxidative metabolic profile which uses mitochondrial respiration and fatty acid oxidation to achieve energy. The treatment with process of glycolysis inhibitor compounds in naive CD4+ T cells importantly enhance its development, what also occurs with culture conditions that conduces to a low mTOR signaling (3,8). III. Regulation of cell B by mTORC The PI3K pathway to mTOR is required for B cell proliferation. Since the BCR is blocked by inhibition of mTOR. This was evidenced in mouse spleen cells, wherein inhibition of mTOR suppresses the proliferation and differentiation of B cells by CD40 (10,11). In humans, Rapamycin suppresses B cell proliferation when is activated in the presence of CD40L and B cell inducing cytokines. Rapamycin prevents antibody-mediated apoptosis, generating a reduction of B cells that produce IgG and IgM, also suppresses the production of cytokines that induce proliferation of B cells and IgM, as IL-2 in inflammation conditions (18). Some authors suggest that mTOR regulates IL-17, which is important in the proliferation of pro-B cells. Thus, if rapamycin in B-precursor acute lymphoblastic leukemia cell lines is evidence that IL-17 induces apoptosis in these cells is used. But when S1N1, an important element of mTORC2, is suppressed cell survival is increased possibly by the increased expression of IL-7R (20). In mature B cells, activation of TLRs and BCR induces activation of mTOR, even so, have been identified as Akt independently of mTOR regulates the BCR and this is accomplished by inactivating FoxO1 which is sequestered and degraded in cytoplasm after Akt is phosphorylated (21). When is deleted TSC1 or TSC2, is inhibited the maturation of cells B, contrary to what happened when Akt was active, in where B cells were significantly reduced in the marginal zone (MZ). But when rapamycin was fed this phenomenon was corrected, and once again the importance of mTOR is displayed in the control populations of B cells in MZ. Despite all the evidence to date is known that the PI3K pathway is a major regulatory functions and populations of B cells through regulating FoxO1. But do not have enough information to indicate the direct role of mTOR in the control and regulation of B cells, which is still under study and demonstration (22). IV. Metabolism and APCs Regulation Dendritic Cells (DC): crucial regulators of both cellular activation and tolerance in adaptive immune responses. The function which DC will perform depends on their activation and differentiation status (23). The DC activation occurs through PAMP stimulation of TLR, what leads a metabolic transition in the resting immature DC, which is characterized by a conversion from mitochondrial b-oxidation of lipid and OXPHOS to aerobic glycolysis (9,10). Once exposed to TLR agonists, in an early phase, the lacking of glucose in culture medium leads to critical faults in DC activation, such production of IL-12p40 and surface expression of CD40 and CD86. Afterwards, DCs activated by TLR signals are highly dependent on glucose for survival, becoming more sensitive to apoptosis by nutrient limitation. Thus, for full DC activation is essential initiating glycolysis at the time (9,10). Differently than OXPHOS, glycolytic pathway may be requested due to the necessity to produce substrates which will be used during DC activation. As an option, glycolytic pathway components can control protein translation and can be responsible to regulate the translation of crucial proteins for DC activation (24). Macrophagues: Macrophages can be classified into two major groups M1 (inflammatory) and M2 (anti-inflammatory). And each type of macrophage used different metabolic pathways, M1 uses energy mainly anaerobic glycolysis, mediated by HIF-1ÃŽ ±, while M2 employs FAO mediated PPARÉ ¤ and PGC-1ÃŽ ² (26). Evidencing with this, the relationship with of the metabolic function and and the population of macrophages. This regulation may be mediated by mTOR, which is an important nutrient sensor / power as processes such as protein synthesis, autophagy, glycolysis and regulation of immune response, de novo lipogenesis, among others. (27) Natural killer cells (NK cells): The NK cells rapamycin inhibits proliferation by blockade of the cell cycle in G1 phase in rat. Nevertheless, rapamycin does not affect interferon production by NK cells. When mTOR is inhibited in vitro, the death of T-cell YEC-1mediated by NK cells decreases slightly. In vivo, rapamycin reduces the number of NK cells in rat liver allografts (10). Neutrophils: Human neutrophil is inhibited the chemotaxis and chemokinesis induced by GM-CSF, when rapamycin is delivered. The same way, the response to IL-8. Rapamycin reduces polymerization of actin, important for leukocyte migration. mTORC1 is linked in activation of neutrophils and acute lung injury in association with TLR2 and TLR4 (18). V. Mitochondrial metabolism and regulation of immune response Effect Warburg: Is a termination used to describe a mechanism of some cancer cells to metabolize glucose via glycolysis, where the conversion of glucose to lactate with oxygen available to obtain energy with rapid generation but less efficient pathway for obtaining ATP (20,21). Carbon precursors necessary for the synthesis of nucleic acids, phospholipids, fatty acids, cholesterol and porphyrins can be provides by glycolysis (28). Glycolysis in normal tissues is the metabolism of 6-carbon glucose to 3-carbon pyruvate and the energy in the form of ATP occur via oxidative phosphorylation in mitochondria (30). Hexocinase-2 (HK-2) is an isoform over-expressed in many cancer cells and is located on the external mitochondrial membrane protein VDAC (voltage-dependent anion channel). HK-2 has preferential access to mitochondrial generated ATP via the mitochondrial adenine nucleotide translocator (ANT), and protection from inhibition by its product G-6-P. Cancer cells have overproduced HK-2 and making the reaction between ATP and the incoming glucose to produce G-6-P at a high rate (30). Studies suggest a link between cancer cells and Hif-1a, where high Hif-1a activity is demonstrated to mediate the Warburg effect. HIF-1a is able to produce enzymes hexokinase 2, triosephosphate isomerase, isomerase, glucose 6-phosphate, and pyruvate kinase M2 (PKM2) in glycolysis (31). HIF-1 is a transcription factor responsible for the change of gene expression during cellular response to low oxygen conditions. Amplifies HIF-1 transcription of genes encoding glucose transporters and glycolytic enzymes (32). Recent studies show Warburg effect have many mechanisms: tumor microenvironment and stabilization of HIF, oncogene activation and loss of tumor suppressor genes, mitochondrial dysfunction in cancer cells, nuclear DNA mutations, epigenetic changes, miRNA, glutamine metabolism, and post-translational modifications (28). Metabolic pathways and importance in the differentiation and function of immune cells: The response, proliferation, polarization or action of immune cells requires the supply of nutrients and high energy consumption, for this reason the contribution of ATP for these functions comes from differential form of the various metabolic pathways, from glycolysis, to pyruvate until lactate production or acyl-CoA, to enter the tricarboxylic cycle acid (TCA); or through of the fatty acids oxidation (FAO). Producing enough electrons (NADH and FADH2) to activate of the electron transport chain to fuel oxidative phosphorylation (OXPHOS) (1). It is also already considered that myeloid cells such as granulocytes, dendritic cells, macrophages, B cells and T cells mainly use glycolysis as a source of ATP via anaerobic when they present an effector or inflammatory profile (Figure XX)(1,2). This is evidenced by neutrophils that have few mitochondria and consume little oxygen (34). Under these conditions the Warburg effect is generated. Producing lactate and NADPH, an essential cofactor for the NADPH oxidase for the production of important microbicidal product H2O2 (35). Some authors suggest that eosinophils and basophils are metabolically similar to neutrophils (36) As with neutrophils, macrophages are important in the immune response and are distributed in all organs and tissues. Playing an important role in innate immunity and adopt different states of activation. Interferon-É ¤ (IFN-É ¤), in combination with TLR agonists, induces M1 (inflammatory), while IL-4 and IL-13 cytokines induces M2 (regulators) (37). M1 macrophages secrete IL-12, IFN-gamma promotes, thus inducing NK cells and T cells, addition of TNF-ÃŽ ±, that activate other immune cells, and NO. Contrary M2 macrophages, secret anti-inflammatory molecules and stimulate tissue repair. Activation of M1 and M2 is characterized by the use of different metabolic pathways (38). M1 using arginine as a substrate to produce iNOS occurs only in the M1, and not in M2. M2 using arginine as a substrate for Arginase1 expressed only in the M2, and not in M1(37). The M1 macrophages possess a glycolytic metabolism. Similar to the different types of activated cells such as dendritic cells and granulocytes. (Figure XX). The Macrophage M1 has higher basal mitochondrial oxygen consumption, the other macrophages. M2 macrophages inducing the mitochondrial OXPHOS through of IL-4 and FAO. in such a way, metabolism M2 is strongly biased towards the use of FAO and mitochondrial respiration to meet their energy needs (Figure XX) (39). DCs derived from cultured bone marrow stimulated with colony-stimulating factor granulocyte-macrophage, are a model of production of TNF-ÃŽ ± and inducible nitric oxide synthase (iNOS). At rest, the DCs oxidize glucose in the mitochondria, by OXPHOS, with little lactate production. But, once stimulated with TLR agonists, become dependent on Warburg metabolism to subsistence (40). PI3K and Akt are important in the activation of glycolytic metabolism (41); play an important role in the duration of glycolysis in DCs activated. As evidenced by DCs activated by more than 12 hours which increases glucose consumption and TCA and mitochondrial oxygen consumption cease (40), increasing lactate production, and the cells survive only by aerobic glycolysis (Fig. XX). The high production NO gas by iNOS from arginine, inactive mitochondrial respiration in these cells. So the activation of glycolytic metabolism in activated DCs induces the expression of iNOS and production of NO thus inhibits OXPHO S. This subsistence mechanism is vital for the rapid production of ATP in the absence of machinery for the production of mitochondrial ATP (42). As the cells of the innate immune system, the T and B cells activated Warburg metabolism used at the time of the proliferation. In contrast to most of innate cells, which use Warburg metabolism after activation but not proliferate (1). Contrary to activated effector T cells, memory T and B cells do not use aerobic glycolysis but if they use mitochondrial FAO for their development and persistence, maintain or adopt a catabolic metabolism (Figure XX) (43). Once an antigen recognized by naive T cells and with adequate costimulation, this growth rapid, proliferation, and acquisition of specialized effector functions is initiated. This requires of the T cell a metabolic reprogramming and energetic. This pass of a catabolic metabolism to an anabolic metabolism, changes the cell is not in a state of maintenance and homeostasis (1). Some molecules such P13K, Akt, Myc, and HIF are associated with immune and metabolic signals for the activation, function, development and upkeep of T cells. So the metabolic pathways induce a T helper subsets (1). As was evidenced in Treg cells mainly use mitochondrial OXPHOS and FAO for their development and subsistence (17) or in Th17 cells where glycolysis is primarily required (44). In activated T cells the IL-12 induce an increase in the glucose transporter and glycolytic metabolism. Besides glycolysis in maintaining the activity of active effector T cells, exist other pathways involved, as via the pentose phosphate and glutaminolysis as well as the use of key molecules such as citrate and malate (Figure XX) (1).It is important to consider the available nutrients, substrates, or other resources that can create an imbalance in the environment of immune cells, affecting the metabolism of cell function and fate of immune cells. Mitochondria in the production of iNOS and inflammation: All metabolic process to generate ATP by OXPHOS generates ROS, which are involved in oxidative stress of the mitochondria. Production of O2- in excess, induces activation of factors of redox-sensitive transcription, such as NF-kB, and thus an increase of cytokines, chemokines, inducible nitric oxide synthase (iNOS), eicosanoids, and adhesion molecules (45). Some of these superoxide anions combine with nitric oxide (NO) to produce peroxynitrite (ONOO-), a powerful oxidant. These ROS oxidize proteins, membrane lipid and mtDNA; damaging mitochondrial integrity (46). Being mitochondria, the inducer of the pro-inflammatory action by the action of innate immunity using redox sensitive or direct inflammasome activation molecules. Progression that result in the immediate activation of caspase-1, and subsequent activation of the inactive precursor of IL-1ÃŽ ² and IL-18 (47). DAMPs activate the same receptors that detect PAMPs, such as TLRs and cytoplasmic NOD and NLRs (46). Once activated, NLRP3 this is depolymerized and induces the recruitment of the adapter protein ASC and caspase-1 (and her cleavage), and other cytoskeletal proteins, glycolytic enzymes and caspase-7. This group of proteins called inflammasome. This complex induces pro-inflammatory, such as IL-1ÃŽ ² and IL-18.(47). Elevated levels of ROS generated by the mitochondria activate NLRP3 inflammasome. Interestingly, the humidity and the myth-AMPS can activate APCs, as well as other non-immune cells including mesenchymal stem cells and astrocytes. Additionally, IL-1ÃŽ ² pro-inflammatory IL-6, MCP-1 and TNF is induced by degradation of mtDNA in mouse primary astrocytes. (48). This activation of the inflammasome can activate NF-kB, increasing even more pro-inflammatory cytokines duration of the inflammatory response. This summation of events can be a clear explanation to the high deterioration of mitochondria (46). Biogenesis of mitochondria: The availability of nutrients and oxygen can determine the function of a time cell proliferate and differentiate. Under normal conditions the cell has high level out of ATP/ADP/AMP. Thus, an increase in AMP activates AMPK, activating ATP production by activating TSC 1 and 2 which blocks mTOR (7). After ATP levels are increased activated Akt/PKB promotes mitochondrial biogenesis by phosphorylation and nuclear translocation of NRF-1 and nuclear translocation with increased mitochondrial hexokinase (HK), using glycolysis coupled to OXPHOS with uptake mitochondrial ATP, especially in order to allow cell survival and maintenance of cell functions (49). An important protein in the biogenesis of mitochondria is BAD, which is involved in the initiation of a protein complex that catalyzes the first step of glycolysis by deHK-4 activation. But absent BAD gives a restriction of respiration in the presence of glucose and in the absence of glucose dephosphorylated BAD and induces apoptosis(50). This interaction between energy metabolism and the regulation of apoptosis, is important in mitochondrial biogenesis, and any imbalance can lead to mitochondrial failure and loss problems inducing pathological cell survival (51). Thus, the whole process of inflammation, oxidation and apoptosis, requires a high rate of mitochondrial replacement to allow the restoration of damaged mitochondria continuously and cell survival, which may serve as a signal that stimulates the production of mediators anti-inflammatories such as the IL-10. This is evidenced by the increased immune tolerance during periods of mitochondrial biogenesis may be a risk for recurrent or secondary infections evidencing with them a close relationship between immunosuppression and the regeneration of the mitochondria, this period of immunosuppression may be greater depending the damage level of the mitochondria involved in the initial inflammatory process.(49). VI. References 1. Pearce EL, Pearce EJ. Metabolic pathways in immune cell activation and quiescence. Immunity. Elsevier Inc.; 2013 Apr 18;38(4):633–43. 2. Odegaard JI, Chawla A. The immune system as a sensor of the metabolic state. Immunity. Elsevier Inc.; 2013 Apr 18;38(4):644–54. 3. Oren R, Farnham AE, Saito K, Milofsky E, Karnovsky ML. Metabolic patterns in three types of phagocytizing cells. J Cell Biol. 1963 Jun;17:487–501. 4. Krawczyk CM, Holowka T, Sun J, Blagih J, Amiel E, DeBerardinis RJ, et al. 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Mitochondria in neutrophil apoptosis. Int J Hematol. 2006 Oct;84(3):199–204. 35. Dale DC, Boxer L, Liles WC. The phagocytes: neutrophils and monocytes. Blood. 2008 Aug 15;112(4):935–45. 36. Sumbayev V V, Nicholas SA, Streatfield CL, Gibbs BF. Involvement of hypoxia-inducible factor-1 HiF(1alpha) in IgE-mediated primary human basophil responses. Eur J Immunol. 2009 Dec;39(12):3511–9. 37. Murray PJ, Wynn TA. Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol. 2011 Nov;11(11):723–37. 38. Rodrà ­guez-Prados J-C, Travà ©s PG, Cuenca J, Rico D, Aragonà ©s J, Martà ­n-Sanz P, et al. Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activat

A Comparison of High School and College :: Compare Contrast Comparring Essays

School plays an important role in our lives. Many people will spend more than fifteen years at school in order to get the qualifications that are required to work in a specific field. Those years are broken down into several levels, some of them being more enjoyable than others. Two very important levels that people go through are high school and college. Even though some think that these levels are almost the same, there are significant differences between them. The cost of high school is not the same as the cost of college. Also, some differences apply from an academic point of view. Typically, the social environment also differs from high school to college, which can be related to the question of freedom versus responsibility. High school and college are different in many ways. It is true to say that college is more expensive than high school. Of course, it provides a higher level of education, but that expensive fees make it hard for those that come from low income families. At college you also have to buy books where in high school you borrow them from the school. Paying for education can get expensive, but some people pay even more than imaginable. Some cities do not have colleges, so students that want a higher education have to move away to another city where they can get a higher education. This often involves paying for an apartment, food and transportation. However, the cost is not the only thing to consider when comparing high school to college. As college provides a higher level of education, the amount of homework increases. At high school, where it is more of a general education, the time spent at home doing homework is a lot less. This does not mean that in high school, t here is no work; it just means that it is a lot easier in some sense. At college you can also choose from subjects related to your field of study if you desired. There are also some differences between the social environment of students at high school and students at college. Since college students have more work to do at home, they have a limit on the time they can spend outside of school.

A Passage to India:An Examination of the Work in a Historical Context :: essays research papers

A Passage to India by Edward Morgan Forster is truly one of the great books of it’s time. Written in an era when the world was more romantic, yet substantially less civil to the unwestern world than it is today; E. M. Forster opened the eyes of his fellow countrymen and the world by showing them the truth about British Colonialism. The novel aids greatly in the ability to interpret events of the time as well as understand the differences between the social discourse of then and now.   Ã‚  Ã‚  Ã‚  Ã‚  To fully understand A Passage to India and its cultural and historical significance one must first understand the world in which it was written, and the man who wrote it. Forster published the novel in 1924 England, a place much different than the England of today. At the time the sun still didn’t set on the British empire and there were still serious societal influences form the Victorian Era.   Ã‚  Ã‚  Ã‚  Ã‚  Forster was born on January 1st 1879; his family was part of London's upper-middle class. At the age of two Forster's father died, leaving only his mother to raise him. Their relationship was very strong and stayed that way up until her death in 1945. Forster was educated in Kent up until 1897, and then went on to King’s College at Cambridge.   Ã‚  Ã‚  Ã‚  Ã‚  Immediately after his graduation from the University in 1901, Forster began to travel around the world, spending much of his time in Italy, Greece, and Germany. His first novel, Where Angels Fear to Tread was published in 1905 and was received with good reviews. By the publication of his fourth novel, Howard's End in 1910 Forster had become a member of what was known in writing circles as the Bloomsbury Group, a distinguished group of writers including Virginia Wolf, John Maynard Keynes, and many others. In 1912 Forster made his first visit to India; and in 1021 after having served for the Red Cross in Egypt during world war one, he returned to India to be the private secretary to the Maharajah of Dewas. Forster based A Passage to India on the experiences he had while working for the Maharajah.   Ã‚  Ã‚  Ã‚  Ã‚  The world of Colonial India was much different than that of England at the time, or of the India of today. The country was ruled by the British military. British patriots and ex-patriots living in India had a culture all there own; they were not at all oppressors but did have a completely different culture than the indigenous peoples of the country.

The United States’ International Policies Focused in Iran and Iraq Essa

The United States’ International Policies Focused in Iran and Iraq After World War II the United States promised to not return to its isolationist attitude, which allowed Hitler to gain so much power. They instead decided to take a very active role in the world’s politics. From Korea to Vietnam, the U.S. proved that it would go to extreme lengths to police the world. The past two decades have seen the U.S. deeply involved in the Middle East as they try to stabilize a region ravaged by ethnic battles and power struggles for the world’s oil supply. America has played integral roles in the skirmishes by either trying to organize a peace process or supporting one or both sides. These actions will have consequences. Just as the British world empire crumbled in the early 1900s, the U.S. has chosen a path of expansionism that if not altered will lead to the disintegration of its world dominance in political and economic power. As we all know history has been known to repeat itself. Thus to justify my hypothesis, we must look at the last country to try to control the Middle East, specifically Great Britain. In 1917 the British began their occupation of Baghdad in order to protect the Arabs from the Turks from the Ottoman Empire. By 1920 the British had not fulfilled their promise to leave the area and the people of southern Iraq responded with military action. The British returned with their own aggression, but soon realized that they could not maintain control over the area. In 1921, a popular election was held and Prince Faisal of Hijaz won with 96% of the ballots. Unfortunately the new king of Iraq inherited a kingdom torn by civil war. To understand this internal struggle, look at how the Kurds make ... ...rman of the Joint Chiefs of Staff because he has been through the Persian Gulf, has learned from the mistakes of the United States and will use his knowledge to prevent another debacle from beginning. Bibliography Atkeson, Maj. Gen. Edward B., â€Å"The Persian Gulf: Still a Vital Interest?† Armed Forces Journal International, Vol. 124, No. 9, April 1987 Brown, Harold, â€Å"Thinking About National Security†, Boulder: Westview, 1983, p. 157 Stocking, George W., â€Å"Middle East Oil: A Study in Political and Economic Controversy†, Nashville: Vanderbilt U.P., 1970 p. 103-106 Stork, Joe, â€Å"Middle East Oil and the Energy Crisis†, New York: Monthly Review Press, 1975 http://i-cias.com/e.o/iraq_4.htm http://www.oppression.org/middleeast/kurdish_history.html http://www.infoplease.com/ce6/world/A0859147.html http://www.fas.org/man/dod-101/ops/war/iran-iraq.htm

Google Communication Essay

When you’re talking about a good company to work for, Google is one of the top employers to get in business with and to work for. Everyone wants to read up on Google, every eye is on this one particular company. It has one of most interesting organization cultures out of all cultures. Not to mention, In 2007 Google was ranked in the top 100 best businesses to work for. This statement was written in the fortune magazine. Me personally I say Google communicates very well. Google has the best and the fastest and most reliable search engine that it is. For Google to obtain these accomplishments they look and hire people who are tech savvy and are professionals. What makes Google a successful company? They value their talented employees. They reward them with good things; Google cherished good employees. To keep a business on the right track and successful, employees must be treated equally and be rewarded. Since I’ve known Google to be a search engine I haven’t heard about any downfalls or complaints. The Google management bring themselves together as a team and more so family. From the articles I’ve read, Google strives to give their employees the best experience that they could ever have. That goes for any business existed, you should aim to give your employees the best experience, something that they would never forget. That job that you always talk about and never would let go. Throughout the years we all know that Google has switched up something’s. Google has changed the way we receive information dramatically. Looking in or looking out Google is valued as a great company. Google also communicates well internally and externally. Google uses a number of apps for communication both ways. They have apps for education, business and not limited to marketing. One of my favorite apps is the Gmail app. You can have multiple email accounts and you can store all of your files there. One of most advantages using these apps is you do not need a credit card to use them. I find that Google does espouse and align with the enacted values as they incline to treat all equal and show all ideas with in the company as one. They plan together and they become successful together.

Geological Education Unknown to Man Essay

Certain things in life occur even without our knowledge. Sometimes, these are the experiences that will forever change the course of our lives. I only found out about these as I embarked on a journey to discover the realities of life. I bore witness to the hidden beauty of the earth as we went on an educational trip to Washington D. C. As we were headed towards our destination, I became excited more than ever. Finally, I would be given the opportunity to explore the wonders that this country has hid from its citizens. First stop we went to was the Potomac River. I was amazed at the Bedrock of Meta-greywacke that welcomed us in the place. The area was definitely sandy, with slight foliations. Pink and Grey sandstones were also available in the area, and I believe that these were formed due to abyssal turbidity currents. The gradient beds get destroyed during metamorphosis. Next stop that we went to was the Rock Creek Shear Zone found in the Amazonia part of the Zoo. I observed that there were Quartz pebbles and granite cobbles found on the rock. We were given information that the fault was 15 km deep, was more ductile, and was more likely to falter. What we saw were more or less elongated, and smeared clasts, that were exposed to the environment due to erosion. In addition to this, we have also observed that some of the metagraywracke contained garnets. Garnets are considered to be medium grade meta minerals that are exposed due to heat and pressure. I was amazed at how such minerals were able to be exhibited in such rocks. As we went on further with the trip, I became more and more inclined into what we were learning. I discovered that Beech St. Tunnel was also made of metagraywreck. This was the rock that seeps out calcite from mortar. In addition to this, this type of rock could also form stalactites. As we went on further with the trip, Potomal formations also caught our attention. These were poorly sorted, having the presence of unlithided river deposits. I also discovered that the bottom of the hill was 460 mya, with the top being 100 mya. In addition to this, the erosion that occurs among the young App would cause unconformities, with the deposits being on top. Furthermore, the thrust fault of the potomal form found under the metagraywracke river removed the weight from the crust, which was then rebounded causing the fault. On the other hand, the rocks that contained serisites were formed due to the chemical stabilities present, as combined with low temperature and pressure. This kind of change was formed starting as a storalite. Storalites are considered to be high grade meta minerals, which easily change shape due to the cooling temperature. As we went on, I saw observed that there were rocks that shad more clasts. The Kink Bandine was created when a highly foliated rock was compressed in the direction of foliaton. I know that it may sound technical, but its not. The movement of the earth has caused the rocks to be stretched, changing their physical appearance. The Kensington Tonalite, on the other hand, was another site to marvel. This is the granite gneiss found in Rock Creek, which was north-south direction of the D. C. I was impressed with natural changes that occur in the earth as time passes by. The trip made us believe further that even the slightest changes in temperature and pressure could alter the rocks greatly. The clasts become stretched further, expanding them to greater heights. Moreover, we are brought to a conclusion that these natural beauties can stand the test of time. Pyrite porphyroblasts are also visible in metagraywracke. These come in square shapes, but are not to be considered as sedimentary grains. One classic example of their strength is the ability to hold the bridge. Unknown to many, the bridge was made mostly of rocks. The strength that this creation has is incredibly impressive, and would definitely grab the attention of geologists and students alike. As mentioned earlier, the shapes and sizes of these rocks have been naturally altered by erosion and weathering. More and more rocks have been exposed, that have been hidden for the past how many years. These are the wonders that have been hidden from the rest of the world that others did not witness. The kind of exposure trip provided for us was something that I will forever keep in my heart. I was able to learn new things that were unknown to me before. In addition to this, we were able to see first hand the different geological specimens discussed in class. Sometimes, learning should not only be done in school, but also in the real world. The trip has been effective in our application of the knowledge done in school. Aside from the experience, the trip also made us feel good about ourselves. Regardless of all the scientific and logical explanations that we had towards our environment, there are still certain things that we have no control of. I marvelled at how nature would take its course in allowing us to bear witness to things and circumstances that were beyond our reach. From everything that has been said and discovered, I believe that these educational trips are effective in promoting the education of students. Theoretical education is being applied through the exposure of such wonders. Besides, knowledge is not just learned within the walls of the classroom. Knowledge is best learned through the application of knowledge and the exploration of things and circumstances that we are unaware of.